Tramadol is an effective drug for a wide range of pains when taken according to the recommended prescriptions. The interaction of tramadol with other prescribed or nonprescribed drugs, herbal medicine or food substances such as some vitamins may cause challenging effects. Certain diseases may also interfere with the effectiveness of the medication to fight pain. Some substances may increase the side effects of tramadol while tramadol may cause the poor experience to patients using certain medications. It is important, therefore, to have the following knowledge in mind before using tramadol medication.

Drugs to avoid Taking alongside Tramadol

Taking carbamazepine when using tramadol reduces the effectiveness of the drug. Carbamazepine medication has a tendency to reduce the amount of tramadol in the body while increasing the risk of experiencing a seizure.

Medication with Side Effects Increased By Tramadol

Using tramadol alongside other drugs may increase the risk of experiencing the side effects caused by those medicines. Such drugs include venlafaxine, citalopram, sertraline, escitalopram, paroxetine and duloxetine taken to treat depression. These drugs may cause a serotine syndrome characterized by restlessness, elevated body temperatures, fast heartbeat or nausea. Selegiline, isocarboxazid, phenelzine and similar Monoamine oxidase inhibitors are also linked to the serotine syndrome.

Other medications linked to induction of serotine syndrome when taken with tramadol include St John’s wort, lithium, Linezolid, and drugs for headaches such as rizatriptan, sumatriptan, and zolmitriptan. These medications must be taken only under the doctor’s close monitoring when tramadol is introduced as a supplement.

Taking tramadol when using anti-psychotics such as thioridazine or chlorpromazine, hypnotic drugs such as zolpidem, anesthesia medication such as pentothal, succinylcholine or propofol is linked to decreased blood pressure, shallow breathing or confusion to the patient. Use of tramadol alongside diazepam, alprazolam, lorazepam, clonazepam among other benzodiazepines or opioids such as oxycodone, hydrocodone or morphine may cause severe side effects such as coma or death. Some other drugs that may cause severe side effects when tramadol is introduced into the medication include warfarin and digoxin. It is important to tell your doctor if you are using these drugs before taking tramadol.

Drugs Increasing Tramadol Side Effects

There are some drugs that can show mild to serious side effects when introduced to the tramadol medication. Such drugs mostly increase the amount of the tramadol active ingredients thereby acting as an inducer of effects of an overdose. They include drugs such as antidepressants such as amitriptyline, antibiotics such as erythromycin, heart drugs such as quinine and antifungals such as ketoconazole. Similar drugs include protease inhibitors such as darunavir, ritonavir, and atazanavir.

Tramadol with Alcohol

Use of alcoholic substances may increase the side effects of tramadol by interfering with the nervous system. The patient may become drowsier, feel dizzy and experience difficulties to concentrate. In the event of such occurrences, the patient should not be allowed to operate machines or drive.

Alcohol intoxication that is severe and showing depressed vital signs may cause addiction to tramadol when the drug is used as a depressant of the central nervous system. It may also cause serious depressed breathing or death of the patient. Medication that can be used to reverse the effect of tramadol-induced depression to the breath of an acute alcoholic is naloxone which serves only a partial effect.

Tramadol Interactions with Health complications

You should consider seeing your doctor if suffering from liver disease, respiratory depression, acute abdominal conditions, intracranial pressure, seizure disorders, renal dysfunction or suicidal feelings.

Tramadol takes long to decompose in patients suffering live problems, cause problems in urine production where the patient is suffering kidney problems while patients using tramadol experience an increased risk of seizures. Abdominal pain may increase with the use of tramadol. Persons with a history of emotional disturbances or with ideation of suicide or have been misusing tranquilizers should take tramadol only under the doctor’s watch as their metal problems may worsen.

While tramadol can be bought over the counter without the doctor’s prescription, users should be cautious of the risks involved. It is important to receive a medical checkup before using tramadol or get advice from the nearest pharmacist.