Recently, an interesting result of a medical research that was carried out in the University of Texas was published. It was discovered that the origin of pain differs between men and women at the cellular level. During the research, it was discovered that manipulating specific receptors of the neurotransmitter dopamine in the nervous system has considerable effects on chronic pain in male mice but this action has no effect in female mice.
According to an associate professor of neuroscience in the School of Behavioral and Brain Sciences, the result of the research corroborates what another recent research showed. The research showed that there is a difference between origin of pain in females and males.
The professor went further to say that the mechanisms that initiate and drive pain are different in males than in females. He said the cellular change they made to reverse the genesis of chronic pain only worked in males and has no effect in females. So, it has just been discovered that there are certain cells that initiate and control the development of pain.
The newly found pain mechanism that is related to D5 dopamine receptors was used for the experiment. It is actually one of the classes of receptors that is responsible for pain in men. Pain is believed to originate from these D5 receptors. So, the receptors were genetically removed from both male and female mice. As expected, this led to reduced pain in male mice but it was shocking that female mice didn’t encounter any effect at all.
The good news is that the experiment showed that manipulating D5 receptors can help reduce pain in men. There have been several researches on this issue but none of them led to a clear and conclusive result like the one that was carried out in the University of Texas. As an explanation of this anomaly, the associate professor said the previous researchers only used male mice in preclinical research and the implementation was done on women because they are more prone to chronic pain than men. So, they could not arrive at any convincing result.
But now the reason is clear. If they had done it on female mice they would have figured out that it works on only male mice. There is no doubt, this discovery will soon lead to the use of different pain-relieving therapies for males and females.
According to the professor, it will be a good idea to develop gender-specific drugs for pain where gender is considered for prescriptions. It is not also out of place to look for the cells that are responsible for prolonging pain in each individual so that pain-relieving therapies can be based on the cells.